MK-677 (Ibutamoren): 15mg tablets. Each order contains 30 hard pressed tablets; tablets contain 15mg of Ibutamoren also known as (MK-677).
Inactive ingredients: Microcrystalline cellulose, magnesium stearate, Silica Di Oxide, Di-calicum Phosphate and USP grade food coloring.
All of our products are laboratory tested. We are working to make test results available to our customers. When labs are available you will be able to find them here. Link to lab
MK-677 (Ibutamoren)
1. What It Does
MK-677, also known as Ibutamoren Mesylate, is a non-peptide growth hormone secretagogue that mimics the action of the hunger hormone ghrelin. It stimulates the growth hormone (GH) and insulin-like growth factor 1 (IGF-1) axis by acting on the ghrelin receptor (GHS-R1a) in the brain.
Unlike injectable growth hormone or peptide secretagogues like GHRPs, MK-677 is orally bioavailable, making it more convenient to administer. It does not suppress natural testosterone production and is not a SARM, though it is often grouped with them due to its use in performance-enhancing circles.
Mechanism of action:
Binds to ghrelin receptors → increases GH release
Elevates IGF-1 levels in the liver
Promotes anabolic activity (muscle growth, fat metabolism, cell regeneration)
2. Main Reported Benefits
Increased Growth Hormone & IGF-1 Levels: Leads to improved muscle growth, fat metabolism, and cellular repair.
Muscle Mass Retention and Gain: Promotes lean body mass in both healthy individuals and those with wasting conditions.
Improved Sleep Quality: Enhances REM sleep and overall recovery, commonly reported by users.
Faster Recovery: May speed up muscle, tendon, and soft tissue repair after exercise or injury.
Increased Appetite: Due to ghrelin receptor stimulation, often leading to easier bulking.
Potential Anti-Aging Effects: Higher GH/IGF-1 levels may contribute to improved skin elasticity, bone density, and general vitality.
Bone Density Improvement: Especially beneficial for aging populations or those with osteopenia/osteoporosis.
3. Normal Applications
MK-677 has been studied and used in research settings for a variety of medical and performance-enhancing purposes:
Treatment of GH Deficiency: Investigated in both children and adults as a potential therapy to stimulate endogenous GH production.
Muscle Wasting Diseases: Studied for its ability to preserve or increase lean mass in catabolic states.
Osteoporosis and Bone Healing: Examined for its bone-strengthening effects.
Anti-Aging Research: Explored for its regenerative properties related to tissue, skin, and energy metabolism.
Bodybuilding and Athletic Use: Popular in non-medical contexts for bulking, recovery, and overall performance improvement.
MK-677 is not FDA-approved and is considered a research chemical. It is legal to purchase for research purposes but not for human consumption or sale as a dietary supplement.
4. Common Side Effects
While MK-677 is generally well-tolerated, especially compared to synthetic GH injections, side effects may still occur, particularly with prolonged use:
Increased Appetite: One of the most consistent and prominent effects.
Water Retention and Bloating: Due to elevated GH/IGF-1.
Lethargy or Fatigue: Often reported during the first few weeks.
Numbness or Tingling in Extremities: Possibly due to nerve sensitivity from increased GH.
Insulin Resistance or Blood Sugar Elevation: May cause temporary increase in fasting glucose and insulin levels.
Mild Edema or Joint Pain: Due to fluid shifts and growth factor changes.
Caution is advised for individuals with diabetes or prediabetes due to its effect on glucose metabolism.
5. Recommended Administration or Dosage
Note: All information below is based on anecdotal usage and preliminary studies. MK-677 has no approved dosing protocol for over-the-counter or personal use.
Dosage Range: 10–25 mg per day
Administration: Orally, once daily (due to its long half-life)
Timing: Often taken before bed to coincide with natural GH pulses and reduce daytime lethargy
Cycle Length: Many users run it for 8–12 weeks, but it is sometimes used for several months due to its non-suppressive nature
Half-Life: Approximately 24 hours, allowing for once-daily dosing
Unlike many performance-enhancing agents, MK-677 does not require post-cycle therapy (PCT), as it does not suppress testosterone or other hormones directly.
Final Notes and Disclaimer
MK-677 is a potent and promising compound for increasing growth hormone levels without injections. It is being studied for a range of applications, from muscle preservation and bone health to cognitive and metabolic support. However, long-term safety in humans remains unclear.
